Conventional Test Method:

Oral Polio Neurovirulence Test (Monkey intracerebral)

Alternative Test Method:

Name & Description:

TgPVR21 Mouse Neurovirulence Test

Description coming soon

Validation Status:

WHO: Validated for types 1, 2 and 3 oral polio virus vaccines (2003)

Regulatory Status:

No information

Effect or Potential Effect on Animal Use:


  • Dragunsky E., Nomura T., Karpinski K., Furesz J., Wood D.J., Pervikov Y., Abe S., Kurata T., Vanloocke O., Karganova G., Taffs R., Heath A., Ivshina A. and Levenbook I. (2003). Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: validation by a WHO collaborative study. Bulletin of the World Health Organization 81(4):251-260.
Information Last Reviewed:
May 2012