• Step 7: Finalize experimental plans and animal use protocol
Incorporate Three Rs alternatives into your animal-based procedures and document the Three Rs search in your animal use protocol. Double-check that your animal use protocol follows relevant CCAC guidelines and policy statements on animal use protocols and any policies or standard operating procedures (SOPs) at your home institution. Consider how a description of the Three Rs alternatives used could be included in any future publications about your work.
References used in the preparation of the Three Rs Search Guide: 
- Allen T. and Jensen D. (2006) Searching bibliographic databases for alternatives. Animal Welfare Information Centre Bulletin 12(3-4):1-2, 9-16.
- Bottrill K. (2004) Search strategies on the internet: general and specific. Alternatives to Laboratory Animals (ATLA) 22(Suppl.):S585-589.
- Grune B., Fallon M., Howard C., Hudson V., Kulpa-Eddy J., Larson J., Leary S., Roi A., van der Valk J., Wood M., Dorendahl A., Kohler-Hahn D., Box R. and Spielman H. (2004) Report and recommendations of the international workshop "Retrieval approaches for information on alternative methods to animal experiments". Alternatives to Animal Experimentation (ALTEX) 21(3):115-127.
- Hakkinen P. and Green D. (2002) Alternatives to animal testing: information resources via the internet and world wide web. Toxicology 173(1-2):3-11.
- Hart L., Wood M. and Weng H.-Y. (2005) Effective searching of the scientific literature for alternatives: search grids for appropriate databases. Animal Welfare 14(4):287-289.
- Jensen D. and Animal Welfare Information Center (AWIC) (2005) Worksheet and Instructions for Alternatives Literature Searching. Beltsville MD: United States Department of Agriculture (USDA), National Agriculture Library.
- Jensen D. (2006) An alternatives search example for advanced trauma life support training. Animal Welfare Information Centre Bulletin 12(3-4):3-5.
- Kilkenny C., Browne W.J., Cuthill I.C., Emerson M. and Altman D.G. (2010) Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research. PLoS Biology 8(6).
- Langley G., Broadhead C., Bottrill K., Combes R., Ewbank R., Hawkins P., Hubrecht R., Jennings M., Newman C., Rowe S., Southee J., Todd M. and Ward L. (1999) Accessing information on the reduction, refinement and replacement of animal experiments: Report and recommendations of a Focus on Alternatives workshop. Alternatives to Laboratory Animals (ATLA) 27(2):239-245.
- Smith A. and Allen T. (2005) The use of databases, information centres and guidelines when planning research that may involve animals. Animal Welfare 14(4):347-359.
- University of California Centre for Animal Alternatives (n.d.) Search for alternatives: A step-by-step approach to alternatives searches.
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