Imaging Technologies


Use of imaging (e.g., bioluminescence and magnetic resonance imaging [MRI]) can be considered a Reduction alternative because it allows serial studies on one animal, therefore decreasing inter-animal variation and the overall number of animals needed to achieve statistical significance. In addition, because diseases and responses to exogenous substances can be monitored in a temporal and spatial manner, a greater amount of data can be obtained from smaller numbers of animals, with no need for invasive surgery and/or serial sacrifice.

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