Vaccine Safety - Human Use

Conventional
test method

Alternative Test Method

Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
Abnormal Toxicity Test for Human Use Vaccines Deletion of test
Description and references
No information EU: Included in PhEur monograph: Vaccines for veterinary use. (2005) Replacement  May 2012
Oral Polio Neurovirulence Test
(Monkey intracerebral)
Mutant Analysis by PCR and Restriction Enzyme Cleavage
(MAPREC test)
Description and references
WHO: Validated for type 3 oral polio virus vaccines No information Reduction May 2012
TgPVR21 Mouse Neurovirulence Test
Description and references
WHO: Validated for types 1, 2 and 3 oral polio virus vaccines (2003) No information Replacement May 2012
Residual Toxicity in Diptheria Vaccine
(Guinea pig)
Vero Cell Test of Diphtheria Toxoid Vaccines
Description and references
No information EU: Accepted into PhEur Replacement May 2012

 

List of Abbreviations

Test Methods Categories

Toxicity
Dermal Tests
Vaccines