Conventional Test Method:

Combination Tetanus and Diphtheria vaccines – separate serology tests  for each vaccine

Alternative Test Method:

Name & Description:

Tetanus and Diphtheria Serology test – single test for combination vaccine

For combination vaccines containing diphtheria and tetanus components, the serological assays listed in the PhEur under “2.7.6 Assay of Diphtheria, Method C” can be performed with the same group of animals used for the serological assay of the tetanus vaccine (adsorbed) when the common immunization conditions for the diphtheria and the tetanus components (e.g. doses, duration) have been demonstrated to be valid for the combined vaccine. 

Validation Status:

No information

Regulatory Status:

EU: Accepted into  PhEur

Effect or Potential Effect on Animal Use:

Reduction

References:
  • Council of Europe (CE) (2008) 2.7.6 Assay of Diphtheria vaccine (adsorbed). In: European Pharmacopoeia, 6th ed. Strasbourg, France: CE.
Information Last Reviewed:
May 2012