Conventional Test Method:
Lethal challenge test for Rabies Vaccine
Alternative Test Method:
- Name & Description:
Humane Endpoints for Rabies Potency Testing
Observation of clinical signs and application of an end-point earlier than death to reduce animal suffering.
- Validation Status:
US: ICCVAM initiative
- Regulatory Status:
EU: Accepted in PhEur
US: Accepted (9 CFR 117.e)
- Effect or Potential Effect on Animal Use:
- Council of Europe (CE) (2008) 2.7.6 Assay of Diphtheria vaccine (adsorbed). In: European Pharmacopoeia, 6th ed. Strasbourg, France: CE.
- Office of the Federal Register (U.S.) (2008) Title 9 – Animals and Animal Products, Pt.1-199. In: Code of Federal Regulations (C.F.R.), Revised as of January 1, 2009.
- Information Last Reviewed:
- May 2012