Conventional Test Method:

Prenatal Developmental Toxicity Study (OECD TG 414)

Alternative Test Method:

Name & Description:

Whole Rat Embryo Embryotoxicity Assay

A morphological scoring system is used to assess signs of malformation or retardation in embryos exposed to the test compound over a 48 hr period as well as embryonic death.

Validation Status:

EU: Validated by ECVAM for identifying strong, weakly and non-embryotoxic chemicals (2000)

Regulatory Status:

No information

Effect or Potential Effect on Animal Use:

Refinement
(Uses embryos from killed animals)

References:
Information Last Reviewed:
May 2012