Conventional Test Method:

Prenatal Developmental Toxicity Study (OECD TG 414)

Alternative Test Method:

Name & Description:

Micromass Embryotoxicity Assay

This method uses rat micromass cultures of limb bud and detects the inhibition of cell differentiation and growth, which are parameters suitable for teratogenicity testing.

Validation Status:

EU: Validated by ECVAM for identifying strong embryotoxic chemicals (2002)

Regulatory Status:

None

Effect or Potential Effect on Animal Use:

Refinement
(Uses embryos from killed animals)

References:
Information Last Reviewed:
May 2012