Conventional Test Method:
Prenatal Developmental Toxicity Study (OECD TG 414)
Alternative Test Method:
- Name & Description:
Frog Embryo Teratogenesis Assay- Xenopus (FETAX)
A 96-hour whole-embryo developmental toxicity test that uses early-stage embryos of the South African clawed frogs (Xenopus laevis) to measure the effects of chemicals on mortality, malformation, and growth inhibition. It has been proposed as a screening assay to identify potential human teratogens and developmental toxicants.
- Validation Status:
US: ICCVAM review concluded that FETAX was not sufficiently validated or optimized for regulatory purposes. Future activities were recommended (2000).
- Regulatory Status:
- Effect or Potential Effect on Animal Use:
- Information Last Reviewed:
- May 2012