Reproductive and Developmental Toxicity

Conventional
test method

Alternative Test Method

Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use

One-Generation Reproduction Toxicity Study (OECD TG 415) AND
Two-Generation Reproduction Toxicity Study (OECD TG 416)

Developmental Neurotoxicity Study (OECD TG 426) AND
Prenatal Developmental Toxicity Study (OECD TG 414)

Extended One-Generation Reproduction Toxicity Study
Description and references
No information OECD: TG 443 Reduction
(Use of fewer animals; more data collected from each animal)
May 2012
Repeated Dose 28-day Oral Toxicity Study in Rodents
(OECD TG 407) AND Reproduction / Developmental Toxicity Screening Test
(OECD TG 421)
Combined Repeated Dose Toxicity Study with the Reproduction/ Developmental Toxicity Screening Test
Description and references
No information OECD: TG 422 (1996) Reduction May 2012
Prenatal Developmental Toxicity Study
(OECD TG 414)
Embryonic Stem Cell Test (EST)
Description and references
EU: Endorsed as valid by ECVAM  for identifying non-, weakly and strongly embryotoxic chemicals
(2002)
None Reduction
(For use as in vitro component of in vitro/in vivo reproductive toxicity testing strategy)
May 2012
Micromass Embryotoxicity Assay
Description and references
EU: Validated by ECVAM for identifying strong embryotoxic chemicals (2002) None Refinement
(Uses embryos from killed animals)
May 2012
Whole Rat Embryo Embryotoxicity Assay
Description and references
EU: Validated by ECVAM for identifying strong, weakly and non-embryotoxic chemicals (2000) No information Refinement
(Uses embryos from killed animals)
May 2012
Frog Embryo Teratogenesis Assay- Xenopus (FETAX)
Description and references
US: ICCVAM review concluded that FETAX was not sufficiently validated or optimized for regulatory purposes. Future activities were recommended (2000). None Replacement

OR

Reduction

May 2012

 

List of Abbreviations

Test Methods Categories

Toxicity
Dermal Tests
Vaccines