CertiChem Inc. MCF-7 Cell Proliferation Assay of Estrogenic Activity
This measures whether, and to what extent, a substance induces cell proliferation via estrogen receptor (ER) mediated pathways. Testing is done using MCF-7 cells, an immortalized human breast adenocarcinoma cell line that endogenously expresses ERs.
US: An intralaboratory validation study has been initiated at CertiChem laboratories. ICCVAM has recommended that the assay be given a high priority for additional validation.