Skin Irritation

Conventional
test method

Alternative Test Method

Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
Acute dermal irritation/corrosion (Draize rabbit skin irritation test)  
(OECD TG 404)
EPISKINTM
Description and references
EU: Endorsed as valid by ECVAM for the prediction of both irritant and non-irritant substances (April 2007) OECD: TG 439 (2013)

EU: Test method B.46 in COM regulation 440/2008/EC (2008)

Replacement

OR

Reduction
(When part of a tiered testing strategy that results in use of  fewer animals)

June 2014
EpiDermTM (SIT)
Description and references
EU: Endorsed as valid by ECVAM for prediction of R38 skin irritating and no-label (non-skin irritating) test substances (2008) OECD: TG 439 (2010)

EU: Regulatory accepted as dermal percutaneous absorption test for the REACH program in place of in vivo animal studies (2008)

Replacement

OR

Reduction
(When part of a tiered testing strategy that results in use of  fewer animals)

May 2012
SkinEthicTM RHE (Reconstituted Human Epidermal) model
Description and references
EU:  Endorsed as valid by ECVAM for prediction of R38 skin irritating and no-label (non-skin irritating) test substances (2008) OECD: TG 439 (2010)

EU: Test method B.46 in COM regulation 440/2008/EC (2008)

Replacement

OR

Reduction
(When part of a tiered testing strategy that results in use of  fewer animals)

May 2012

 

List of Abbreviations

Test Methods Categories

Toxicity
Dermal Tests
Vaccines