Skin Absorption

Conventional
test method

Alternative Test Method

Last Reviewed
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
Skin Absorption: In Vivo Method (OECD TG 427) Skin Absorption: In Vitro Method
Description and references
OECD: Endorsed as equivalent to validated (2002) OECD: TG 428

EU: Regulatory accepted as dermal percutaneous absorption test for the REACH program in place of in vivo animal studies (2008)
Replacement
(When human skin is used)

OR

Reduction and Refinement
(When skin from humanely killed animals is used)

May 2012

List of Abbreviations

Test Methods Categories

Toxicity
Dermal Tests
Vaccines