Three Rs Microsite
Your link to information on replacement,
reduction and refinement alternatives
for animal use in science
News & Publications
AltTox.org revised Table of Validated and Accepted Alternative Methods
AltTox maintains a table of alternative methods similar to the CCAC Three Rs Microsite Alternative Test Methods Table. Both tables provide information about the alternative tests and whether regulatory agencies will accept data resulting from the use of these tests.
August 22, 2016
Head mask for cancer patients adapted as a refinement for primate research
A study published recently in the Journal of Neuroscience Methods describes a new Non-invasive Head Immobilization System (NHIS) as an alternative to surgery for macaque monkeys used in neurobiology research.
August 15, 2016
Animal models for CNS safety pharmacology under the spotlight
The pharmaceutical industry has been working to assess the relevance of rodent central nervous system (CNS) safety pharmacology studies in predicting what happens in first-in-human phase I studies. The findings published in Regulatory Toxicology and Pharmacology have important implications for reducing attrition in the drug development pipeline and in reducing animal use.
August 11, 2016
Automated monitoring of mouse behaviour in social home cage groups
A paper reporting a new automated home cage behavioural monitoring system for mice has been published in the journal Frontiers in Behavioural Neuroscience.
August 2, 2016
Does age matter? Working group publish findings to improve reproducibility
A recent paper published in Laboratory Animals summarises the findings of an NC3Rs expert working group investigating the consideration of rodent age in studies.
The paper reviews the factors that affect the decision on the age of the animals selected and how age can impact scientific outcomes.