Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science


Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
American Association for Laboratory Animal Science (AALAS)

65th National Meeting
October 19-23, 2014
San Antonio, TX


Animal Replacement Science Symposium

Improving relevance to human disease - challenges, innovations and applications
London, UK
November 21, 2014


OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 2015
Baltimore, MD

News & Publications

October 20, 2014

A recent Nature News Blog discusses Work still needed to reduce animals in research.

Browse strategies for investigators to reduce animal use.


October 14, 2014

Visit the redesigned AltTox website for current information about non-animal methods for toxicity testing.


October 6, 2014

Read about the seven principles for establishing an Institutional framework for the Three Rs developed by the NC3Rs.


October 3, 2014

The September 2014 issue of Perspectives in Laboratory Animal Science (PiLAS) is now online.


Recent publications:


News Archive
Three Rs Searches Three Rs
 Searches

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods