Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events

3R Symposium by the Danish 3R-Center

Copenhagen, Denmark
September 13-14, 2016

Safety Pharmacology Society Meeting 2016

Vancouver, BC
September 18-21, 2016

2nd RSPCA/APHA meeting on the welfare of wild animals used in scientific procedures

September 22, 2016

Asian Congress 2016 on Alternatives and Animal Use in the Life Science

Karatsu, Saga, and Fukuoka, Japan
November 15-18, 2016

10th World Congress on Alternatives and Animal Use in the Life Science

The 3Rs in Action
Seattle, WA
September 2017

News & Publications

August 29, 2016 revised Table of Validated and Accepted Alternative Methods

AltTox maintains a table of alternative methods similar to the CCAC Three Rs Microsite Alternative Test Methods Table. Both tables provide information about the alternative tests and whether regulatory agencies will accept data resulting from the use of these tests.

August 22, 2016

Head mask for cancer patients adapted as a refinement for primate research

A study published recently in the Journal of Neuroscience Methods describes a new Non-invasive Head Immobilization System (NHIS) as an alternative to surgery for macaque monkeys used in neurobiology research.

August 15, 2016

Animal models for CNS safety pharmacology under the spotlight

The pharmaceutical industry has been working to assess the relevance of rodent central nervous system (CNS) safety pharmacology studies in predicting what happens in first-in-human phase I studies. The findings published in Regulatory Toxicology and Pharmacology have important implications for reducing attrition in the drug development pipeline and in reducing animal use.

August 11, 2016

Automated monitoring of mouse behaviour in social home cage groups

A paper reporting a new automated home cage behavioural monitoring system for mice has been published in the journal Frontiers in Behavioural Neuroscience.

August 2, 2016

Does age matter? Working group publish findings to improve reproducibility

A recent paper published in Laboratory Animals summarises the findings of an NC3Rs expert working group investigating the consideration of rodent age in studies.

The paper reviews the factors that affect the decision on the age of the animals selected and how age can impact scientific outcomes.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods