Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
9th World Congress on Alternatives and Animal Use in the Life Sciences

Humane Science in the 21st Century
August 24-28, 2014
Prague, Czech Republic

American Association for Laboratory Animal Science (AALAS)

65th National Meeting
October 19-23, 2014
San Antonio, TX

OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 2015
Baltimore, MD

News & Publications

July 29, 2014

The 9th World Congress on Alternatives and Animal Use in the Life Sciences scientific program includes a theme on Refinement & Welfare.

Refinement information can also be found in the Care & Techniques and Animal Index sections of the Three Rs microsite.

July 22, 2014

Call for proposals for CAAT 2015 Science-based Refinement Awards — Deadline October 17, 2014.

For other Three Rs research funding opportunities see the Three Rs Microsite Funding page.

July 15, 2014

Read the newly published paper The Need for Randomization in Animal Trials: An Overview of Systematic Reviews by Hirst et al. 2014.

Learn more about Systematic Reviews and Experimental Design.

July 8, 2014

The US granting agency NIH is now developing policies to require that a balance of male and female cells and animals be used in preclinical studies in all future grant applications.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods