Three Rs Microsite
Your link to information on replacement,
reduction and refinement alternatives
for animal use in science
News & Publications
The Design of Animal Experiments: Reducing the use of animals in research through better experimental design
The Second Edition of this publication on experimental design is now available. Revised by the original authors, Michael Festing et al., The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary.
September 12, 2016
In 2013, the NC3Rs and Newcastle University co-hosted a workshop on the welfare implications of different euthanasia methods for mice, rats and zebrafish. The recently published report presents a summary of findings presented at the meeting, an overview of the current (2016) understanding of the welfare impact of various euthanasia methods, along with recommendations to help inform good practice.
August 29, 2016
AltTox.org revised table of Validated and Accepted Alternative Methods
AltTox maintains a table of alternative methods similar to the CCAC Three Rs Microsite Alternative Test Methods Table. Both tables provide information about the alternative tests and whether regulatory agencies will accept data resulting from the use of these tests.
August 22, 2016
Head mask for cancer patients adapted as a refinement for primate research
A study published recently in the Journal of Neuroscience Methods describes a new Non-invasive Head Immobilization System (NHIS) as an alternative to surgery for macaque monkeys used in neurobiology research.
August 15, 2016
Animal models for CNS safety pharmacology under the spotlight
The pharmaceutical industry has been working to assess the relevance of rodent central nervous system (CNS) safety pharmacology studies in predicting what happens in first-in-human phase I studies. The findings published in Regulatory Toxicology and Pharmacology have important implications for reducing attrition in the drug development pipeline and in reducing animal use.