Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 20 15
Baltimore, MD

CALAS 54th Annual Symposium

One World One Vision
May 30-June 2, 2015
Montréal, QC

News & Publications

November 17, 2014

Read AltTox’s new Journal Watch feature which highlights recent journal articles that advance the development or evaluation of non-animal toxicity test methods and approaches.

Additional information on non-animal and alternative testing methods can be found in the Alternative Test Methods Table.

November 11, 2014

Funding opportunity: The American Fund for Alternatives to Animal Research (AFAAR) is accepting applications for the 2015-16 Fellowship Grant for Alternatives to Animal Research in Women’s Health and Sex Differences..

Deadline to apply is December 15, 2014.

October 27, 2014

Read the new 10-year strategic plan to advance the Three Rs recently published by the UK’s NC3Rs.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods