Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
Animal Replacement Science Symposium

Improving relevance to human disease - challenges, innovations and applications
London, UK
November 21, 2014

OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 2015
Baltimore, MD

News & Publications

October 27, 2014

Read the new 10-year strategic plan to advance the Three Rs recently published by the UK’s NC3Rs.

October 20, 2014

A recent Nature News Blog discusses Work still needed to reduce animals in research.

Browse strategies for investigators to reduce animal use.

October 14, 2014

Visit the redesigned AltTox website for current information about non-animal methods for toxicity testing.

October 6, 2014

Read about the seven principles for establishing an Institutional framework for the Three Rs developed by the NC3Rs.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods