Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
AALAS 66th National Meeting

Phoenix, AZ
November 1-5, 2015

Pan-American Conference for Alternative Methods

Baltimore, MD
April 12-14, 2016

CALAS 55th Annual Symposium

Toronto, ON
June 11-14, 2016

10th World Congress on Alternatives and Animal Use in the Life Science

The 3Rs in Action
Seattle, WA
September 2017

News & Publications

September 28, 2015

Learn how the Three Rs is driving new science with these project examples from the NC3Rs research portfolio.

September 14, 2015

Read this summary of a new article on non-animal approaches for acute toxicity prediction across multiple species.

August 31, 2015

Read the latest issue of Animal Welfare.

August 24, 2015

Visit the NC3Rs new Microsampling web resource to learn how microsampling techniques can contribute to reduction and refinement.

August 10, 2015

A new, open-access review of applying refinement to the use of mice and rats in rheumatoid arthritis research is now available.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods