Three Rs Microsite
Your link to information on replacement,
reduction and refinement alternatives
for animal use in science
Our new address as of March 31, 2014:
Our phone number and extensions remain the same.
News & Publications
Three Rs-related Research Funding Opportunities.
March 5, 2014
Recent papers point to the commonly used anesthetic and euthanizing agent TMS (MS-222) as being aversive to zebrafish. The papers point to clove oil and metomidate hydrochloride (or etomidate) as being less aversive alternatives.
The CCAC guidelines on: the care and use of fish in research, teaching and testing point to both MS-222 and metomidate as acceptable anesthetics, registered for veterinary use with fish in Canada. While clove oil is not registered, it is included (with MS-222 and metomidate) as an acceptable method of euthanasia in the CCAC guidelines on: euthanasia.
Febuary 26, 2014
To help identify opportunities for sharing animal resources in Canadian science, the CCAC has now published: