Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science


Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 2015
Baltimore, MD


FRAME Training School in Experimental Design and Statistical Analysis of Biomedical Experiments

30 March – 1 April 2015
Coimbra, Portugal


CALAS 54th Annual Symposium

One World One Vision
May 30 - June 2, 2015
Montréal, QC

News & Publications

January 26, 2015

Read the latest ILAR Journal open access special issue Experimental Design and Statistics.


January 19, 2015

Funding opportunity: The American Association for Laboratory Animal Science (AALAS) is accepting applications for the AALAS Grants for Laboratory Animal Science (GLAS). Deadline to apply is January 25, 2015.

Review additional opportunities for Three Rs funding.


January 12, 2015

Read the latest issue of the ALTEX Journal.


Recent publications:


News Archive
Three Rs Searches Three Rs
 Searches

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods