Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science


Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
9th World Congress on Alternatives and Animal Use in the Life Sciences

Humane Science in the 21st Century
August 24-28, 2014
Prague, Czech Republic


American Association for Laboratory Animal Science (AALAS)

65th National Meeting
October 19-23, 2014
San Antonio, TX


OpenTox USA 2015

Driving the Big Science Challenge in Safety Forward
February 11-12, 2015
Baltimore, MD

News & Publications

August 19, 2014

A new database of Three Rs resources has been produced by Norecopa and the USDA Animal Welfare Information Center.


August 11, 2014

The 9th World Congress on Alternatives and Animal Use in the Life Sciences scientific program includes a theme on Ethics.

Information related to the ethical evaluation of protocols can also be found in the Animal Care Committees section of the Three Rs microsite.


August 5, 2014

Winners of the Alternatives Research & Development Foundation (ARDF) 2014 Alternatives Research Grants have been announced.


July 29, 2014

The 9th World Congress on Alternatives and Animal Use in the Life Sciences scientific program includes a theme on Refinement & Welfare.

Refinement information can also be found in the Care & Techniques and Animal Index sections of the Three Rs microsite.


July 22, 2014

Call for proposals for CAAT 2015 Science-based Refinement Awards — Deadline October 17, 2014.

For other Three Rs research funding opportunities see the Three Rs Microsite Funding page.


Recent publications:


News Archive
Three Rs Searches Three Rs
 Searches

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods