Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events
CALAS 55th Annual Symposium

Toronto, ON
June 11-14, 2016

Focus on severe suffering
An international conference hosted by the RSPCA.

Brussels, Belgium
June 16-17, 2016

Click here to register.

10th World Congress on Alternatives and Animal Use in the Life Science

The 3Rs in Action
Seattle, WA
September 2017

News & Publications

May 24, 2016

Help with reporting animal-based research

Missing important details from publications can mean that results from animal-based studies cannot be replicated, and consequently more animals may be required to repeat the work. A new tool from Penelope assists researchers to report according to the most relevant checklist from the EQUATOR library, and hence assists implement the principle of Reduction.

May 16, 2016

Help with Experimental Design

Want to know the right number of animals to request for your particular study?

Check out the Experimental Design Assistant, a free resource from the NC3Rs to support researchers in the planning of animal experiments - ensuring robust study design and reliable and reproducible findings.

May 8, 2016

RSPCA focus on severe suffering

The RSPCA has recently updated their severe suffering website with two new 'Road Map' resource packs setting out practical steps to help establishments reduce and avoid 'severe' suffering.

Any comments or feedback are welcomed.

May 2, 2016

2017 Science-based Refinement Awards

Attention veterinarians, lab technicians, animal technicians, and all who work with laboratory animals: The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) now is accepting proposals for the 2017 Science-based Refinement Awards.

Deadline is November 18, 2016.

Recent publications:

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods