Three Rs Microsite

Your link to information on replacement,
reduction and refinement alternatives
for animal use in science

Three Rs The Three Rs

Replacing animals in science.

Reducing the number of animals used

Refining care and procedures to minimize pain and distress

Learn more
Upcoming EventsUpcoming Events

45th European Environmental Mutagenesis and Genomics Society Annual Meeting

Bridging genomics, human environmental health risk assessment and the 3Rs in animal science
Copenhagen, Denmark
August 14-18, 2016

20th European Congress on Alternatives to Animal Testing

Linz, Austria
August 24-27, 2016

3R Symposium by the Danish 3R-Center

Copenhagen, Denmark
September 13-14, 2016

2nd RSPCA/APHA meeting on the welfare of wild animals used in scientific procedures

September 22, 2016

10th World Congress on Alternatives and Animal Use in the Life Science

The 3Rs in Action
Seattle, WA
September 2017

News & Publications

July 18, 2016

SynDaver Labs Launches Synthetic Canine Model

The synthetic canine model is an anatomically accurate model that veterinary students can practice surgeries on. The canine model mimics functioning body systems, and has the capability to simulate customized diseases, illnesses and medical complications.

More information can be found on the SynDaver website.

July 11, 2016

Norecopa’s new website

Norecopa is Norway's National Consensus Platform for the advancement of "the 3 Rs" (Replacement, Reduction, Refinement) in connection with animal experiments.

Norecopa's new website includes all the content of the website of the Laboratory Animal Unit at the Norwegian School of Veterinary Science, four databases NORINA, TextBase, 3R Guide and Classic AVs, and all the content of Norecopa's old website ( as well as a brand-new intelligent search engine built specifically for the task of performing one search simultaneously in all these resources.

June 29, 2016

ICCVAM Advisory Committee to Discuss Developing a U.S. National 3Rs Strategy

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 27-28, 2016, at NIEHS in Research Triangle Park, North Carolina. The focus of this year’s SACATM meeting will be to discuss and develop recommendations for implementing a national strategy for replacing, reducing, and refining animal use (3Rs) for regulatory testing.

The SACATM meeting is free and open to the public, and can be attended in person or viewed via webcast. An agenda, other materials, and links to registration for the upcoming meeting will be posted as they are available on the SACATM Upcoming Meetings webpage.

June 20, 2016

CAAT offering training in Tox21 technology

The Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) is offering courses on Tox21 and evidence-based toxicology in The Master of Science in Public Health (MSPH) Track in Toxicity Testing and Human Health Risk Assessment of Environmental Agents. MSPH is a professional degree program that provides individuals with the knowledge and tools needed to be at the forefront of the transition in human health risk assessment.

Click here for complete details, including funding details, part-time options, and admissions and degree requirements. There is still time to apply for fall 2016 admission.

Recent publications:

  • Chen M et al. (2016)
    Tattooing various combinations of ears, tail, and toes to identify mice reliably and permanently. Journal of the America Association for Laboratory Animal Science 55(2):189-198.

News Archive
Three Rs Searches Three Rs

Three Rs Search Guide
Step-by-step strategy for Three Rs information searches

Animal Use Protocol Worksheet
Tool to organize Three Rs information for protocols

CCAC Reference Database
Database of scientific literature used in CCAC publications

Systematic Review
A method of synthesizing scientific evidence

Animal Index
Three Rs information organized by species

Testing Testing

Alternative Test Methods Table
Validated alternatives to conventional regulatory test methods